| LjL | https://ldh.la.gov/news/H5N1-death | 00:03 |
|---|---|---|
| Brainstorm | New from The Lancet (Online): [Comment] Can molecular cancer signals circulating in blood help us prevent cancer-related deaths?: Breakthroughs in laboratory and data science are increasing interest in blood tests to screen for cancer, with colorectal cancer screening at the forefront of [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02708-9/fulltext | 00:37 |
| Brainstorm | (Matrix) <Raf> LjL: do you have any sources on H5N1 and pandemic potential? | 00:38 |
| LjL | Raf, nothing in particular comes to mind (probably my mind's problem), but i've asked elsewhere too and will let you know if anyone mentions anything | 01:05 |
| LjL | Raf, something of concern: | 01:07 |
| LjL | Notes | 01:07 |
| LjL | Supplementary Material | 01:07 |
| LjL | References | 01:07 |
| LjL | Information & Authors | 01:07 |
| LjL | Metrics & Citations | 01:07 |
| LjL | View Options | 01:07 |
| LjL | References | 01:07 |
| LjL | Share | 01:07 |
| LjL | Highly pathogenic avian influenza (HPAI) A(H5N1) emerged in 1997.1 Since then, it has spread globally by migratory birds, resulting in infections in animals on every continent. HPAI A(H5N1) clade 2.3.4.4b emerged in 2021 and resulted in fatal infections in poultry as well as terrestrial and marine mammals.1 In early 2024, influenza A infection was first recognized in dairy cows with mastitis in Texas. Infection in dairy cows is now widespread in the United States, | 01:07 |
| LjL | affecting more than 875 herds in 16 states. Most cow infections are genotype B3.13, whereas most outbreaks in wild birds and poultry are genotype D1.1. | 01:07 |
| LjL | Against this background, more humans have come into contact with HPAI A(H5N1). Investigators now report in the Journal a series of human cases from the United States and Canada.2,3 The former series involves 46 case patients with generally mild, self-limited infection with A(H5N1): 20 with exposure to poultry, 25 with exposure to dairy cows, and 1 with undefined exposure.2 Among case patients with occupational exposure, the use of personal protective equipment | 01:07 |
| LjL | (PPE) was not universal. Most case patients presented with conjunctivitis, almost half with fever, and a minority with mild respiratory symptoms, and all recovered. The only hospitalization occurred in the case patient with undefined exposure, although hospitalization was not for respiratory illness. Of cases with sequenceable virus, most were B3.13; four cases in patients with poultry exposure were D1.1. | 01:07 |
| LjL | In Canada, a 13-year-old girl with mild asthma and obesity presented with conjunctivitis and fever and had progression to respiratory failure.3 She received intubation and venovenous extracorporeal membrane oxygenation. After treatment that included oseltamivir, amantadine, and baloxavir, she recovered. Notably, genotype D1.1 was detected; sequencing of one isolate from the lower airways that was collected 8 days after the onset of symptoms showed three mutations | 01:07 |
| LjL | potentially associated with enhanced virulence and human adaptation: E627K in the polymerase basic 2 gene and E186D and Q222H in the H5 hemagglutinin gene. It is unclear whether these mutations were present in the infecting virus or emerged during the course of the patient’s illness. | 01:07 |
| LjL | oof that was longer than i expected | 01:07 |
| LjL | i only meant to paste "In Canada" onwards | 01:07 |
| LjL | specifically to highlight that there have already been mutations shown causing better specificity to humans | 01:07 |
| Brainstorm | (Matrix) <Raf> When did that infection in Canada happen | 01:11 |
| LjL | Raf, it's been maybe a couple of weeks | 01:40 |
| LjL | err no, not a couple of weeks | 01:41 |
| LjL | more like a couple of months apparently | 01:41 |
| LjL | i've lost track of time | 01:42 |
| Brainstorm | New from BMJ Open: Prevalence of and factors associated with long COVID among diverse healthcare workers in the UK: a cross-sectional analysis of a nationwide study (UK-REACH): Objectives To assess the prevalence of UK healthcare workers (HCWs) who reported symptoms of COVID-19 lasting for longer than 5 weeks and [... want %more?] → http://bmjopen.bmj.com/cgi/content/short/15/1/e086578 | 01:54 |
| Brainstorm | New from r/WorldNews: worldnews: Trudeau's star power dimmed after weathering pandemic and Trump → https://old.reddit.com/r/worldnews/comments/1hvgl0l/trudeaus_star_power_dimmed_after_weathering/ | 03:32 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): This study is largely performed in mice. It is not clear if the vaccine was administered at the same location as the tattoo. If tattoos inhibit local responses will need to be validated in humans and with epidemiological data. → https://mastodon.online/@marc_veld/113785818083945393 | 08:12 |
| Brainstorm | New from EMA: What's new: (news): Human medicines European public assessment report (EPAR): Prevenar 20 (previously Apexxnar), pneumococcal polysaccharide conjugate vaccine (20-valent, adsorbed), Date of authorisation: 14/02/2022, Revision: 9, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/prevenar-20 | 11:59 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): Watch out, this is no RCT, but a case series of 13 individuals with Long COVID who initiated extended courses (>5 days; range: 7.5–30 days) of oral nirmatrelvir/ritonavir outside (n = 11) of and within (n = 2) the context of an acute SARS-CoV-2 infection. → https://mastodon.online/@marc_veld/113786715450773497 | 12:10 |
| Brainstorm | New from PubMed: Targeted therapies and molecular targets in the therapeutic landscape of advanced urothelial carcinoma: state of the art and future perspectives: Advanced urothelial carcinoma (aUC) has a dismal prognosis, with a 5-year survival rate of approximately 10%. Platinum-based chemotherapy has been the backbone of the [... want %more?] → https://pubmed.ncbi.nlm.nih.gov/39764422/ | 12:29 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): Attempts to stimulate the immune system, via vaccination, or reduce any active virus, via antivirals have no or modest success for LC patients. → https://mastodon.online/@marc_veld/113786860614034751 | 12:39 |
| Brainstorm | New from Reddit (test): COVID is a class issue: In my home country in Latin America almost everyone is also pretending that covid isn’t happening and isn’t a thing. Very rare to see a mask in any closed space and people stare when they see me and my family wearing a mask. → https://old.reddit.com/r/COVID19_Pandemic/comments/1hvq81q/covid_is_a_class_issue/ | 13:39 |
| Brainstorm | New from StatNews: STAT+: Johnson & Johnson says its lung cancer drug significantly extended survival: Johnson & Johnson says its bispecific antibody, paired with a Janssen drug, could change treatment for non-small lung cancer patients. → https://www.statnews.com/2025/01/07/lung-cancer-longer-survival-johnson-and-johnson-janssen/ | 14:08 |
| Brainstorm | New from EMA: What's new: (news): Training module EV-M8 - Considerations on the international transfer of personal (health) data in ICSRs -SUSARs originating in the EU → https://www.ema.europa.eu/system/files/documents/other/considerations-international-transfer-personal-health-data-icsrs-en.pdf | 14:28 |
| Brainstorm | New from r/Coronavirus: Coronavirus: What COVID tried to teach us — and why it will matter in the next pandemic → https://old.reddit.com/r/Coronavirus/comments/1hvt6kd/what_covid_tried_to_teach_us_and_why_it_will/ | 15:59 |
| Brainstorm | New from ProPublica: Anchorage Police Say They Witnessed a Sexual Assault in Public. It Took Seven Years for the Case to Go to Trial.: by Kyle Hopkins , Anchorage Daily News This article was produced for ProPublica’s Local Reporting Network in partnership with the Anchorage Daily News . [... want %more?] → https://www.propublica.org/article/anchorage-alaska-pretrial-delays-sexual-assault | 17:20 |
| Brainstorm | New from New Scientist: What is hMPV, the virus spreading through China?: An uptick of human metapneumovirus (hMPV) cases in China has raised concerns over another pandemic, which appear to be unfounded → https://www.newscientist.com/article/2462955-what-is-hmpv-the-virus-spreading-through-china/ | 17:59 |
| Brainstorm | New from Politico: Buildings: Trump trades isolationism for expansionism — possibly with military force → https://www.politico.com/news/2025/01/07/trump-greenland-panama-americafirst-001946 | 21:07 |
| Brainstorm | New from MedPageToday: Herpes and Alzheimer's Tau; Dementia and Autism; Extended Paxlovid for Long COVID: (MedPage Today) -- A study of human brain organoids suggested a complex relationship between herpes simplex virus 1 infection and tau, suggesting that tau phosphorylation may act as an innate immune [... want %more?] → https://www.medpagetoday.com/neurology/generalneurology/113680 | 21:17 |
| Brainstorm | New from CIDRAP: (news): Study: COVID-19 hospital cases, deaths in nursing homes fell sharply after widespread vaccination → https://www.cidrap.umn.edu/covid-19/study-covid-19-hospital-cases-deaths-nursing-homes-fell-sharply-after-widespread | 21:27 |
| Brainstorm | New from University of Washington: Meet the 2024-25 DGH Research Assistants, Fellows, and Awardees: Untitled design.png Each year the University of Washington's (UW) Department of Global Health is able to provide partial to full funding to recruit top applicants. [... want %more?] → https://globalhealth.washington.edu/news/2024/12/30/meet-2024-25-dgh-research-assistants-fellows-and-awardees | 22:47 |
Generated by irclog2html.py 2.17.0 by Marius Gedminas - find it at https://mg.pov.lt/irclog2html/!