| Brainstorm | New from The Lancet (Online): [Comment] Global burden of antimicrobial resistance and forecasts to 2050: The growing challenge of antimicrobial resistance (AMR) is now recognised as a global public health emergency that requires concerted efforts by all stakeholders.1 There is compelling [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01885-3/fulltext | 00:41 |
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| Brainstorm | New from Reddit (test): COVID19_Pandemic: Long-COVID rate among disabled people double that of able-bodied → https://old.reddit.com/r/COVID19_Pandemic/comments/1fiixhw/longcovid_rate_among_disabled_people_double_that/ | 01:10 |
| Brainstorm | New from Nature Vaccines: Peng Wei et al.: An intranasal cationic liposomal polysaccharide vaccine elicits humoral immune responses against Streptococcus pneumoniae → https://www.nature.com/articles/s42003-024-06806-1 | 01:49 |
| Brainstorm | New from r/WorldNews: worldnews: Japan pledges 3 mil doses of mpox vaccine to WHO → https://old.reddit.com/r/worldnews/comments/1filkkb/japan_pledges_3_mil_doses_of_mpox_vaccine_to_who/ | 03:16 |
| Brainstorm | New from StatNews: Opinion: WHO pandemic threat director: Here’s what needs to happen to combat mpox: Global neglect led us to the current mpox outbreak. A global response, based on equity and solidarity, is the only thing that can get us out of it, writes WHO’s… → https://www.statnews.com/2024/09/17/mpox-vaccines-who-drc-collaborative-response/ | 10:39 |
| Brainstorm | New from BMJ: Valproate: Sanofi ordered to pay {euro}285 000 to mother whose children had birth defects: The pharmaceutical company Sanofi has been ordered to pay more than a quarter of a million euros to a mother in France whose children were harmed in the womb by side effects of the epilepsy drug Depakine (sodium [... want %more?] → http://www.bmj.com/content/386/bmj.q2034.short | 11:38 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): Of note, the undermortality "hides" the mortality from COVID-19. This will play a role in the future as well, where the first virus to peak (RSV, Influenza and SARS-CoV-2), may seem worse and the subsequent seem less severe. The overal deaths will need to be considered. → https://mastodon.online/@marc_veld/113152356474209770 | 12:18 |
| Brainstorm | New from BioNTech: BioNTech to Host AI Day as an Edition of its Innovation Series on October 1, 2024: MAINZ, Germany, September 17, 2024 (GLOBE NEWSWIRE) -- BioNTech SE (Nasdaq: BNTX, “BioNTech”), alongside its artificial intelligence [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/biontech-host-ai-day-edition-its-innovation-series-october-1 | 12:56 |
| Brainstorm | New from r/Science: science: COVID-19 vaccine refusal is driven by deliberate ignorance and cognitive distortions → https://old.reddit.com/r/science/comments/1fixr07/covid19_vaccine_refusal_is_driven_by_deliberate/ | 14:46 |
| peetaur | 'doing the thing we know now is correct was done for wrong reasons before' ...so what? | 15:15 |
| Brainstorm | New from Contagion Live: Japan Approves Updated Self-Amplifying mRNA COVID-19 Vaccine: The CSL and Arcturus Therapeutics’ vaccine, ARCT-154 (Kostaive), is designed to offer protection against the JN1 strain. → https://www.contagionlive.com/view/japan-approves-updated-self-amplifying-mrna-covid-19-vaccine | 16:16 |
| Brainstorm | New from EMA: What's new: (news): Human medicines European public assessment report (EPAR): Trumenba, meningococcal group b vaccine (recombinant, adsorbed), Date of authorisation: 24/05/2017, Revision: 17, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/trumenba | 16:26 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): can be tested against other vaccines against the same pathogen. e.g. testing intra-mucular vs intra-nasal. No vaccine will be approved for use without stringent safety testing with good results. After these phase 3 trials, all medicine will remain in phase 4. → https://mastodon.online/@marc_veld/113153376678975021 | 16:36 |
| LjL | peetaur, we don't know now it's correct LOL | 18:19 |
| LjL | don't say shit like that | 18:19 |
| peetaur | the uncertainty is high (because we have no proper interventional study...only industry funded observational and hospital records and such that make unsupportable claims like it has some effect on transmission), but yes with low certainty we know for some age group 20something to 40something | 18:21 |
| peetaur | with false sense of security maybe it even increased the transmission rate...but they don't even study that | 18:22 |
| Brainstorm | (Matrix) <pwr22> Any study that looked at effects on transmission rate would see a correlation in either direction... | 18:24 |
| peetaur | yeah | 18:25 |
| peetaur | with confounders like natural immunity, or the sickest most vulnerable being dead already, you don't know whether it was from a vaccine or not | 18:26 |
| peetaur | also, anything reducing T2D is stronger correlated with good outcome than the vaccine is, so why bother with scaling out experimental drugs when we know a better solution already (yes bother with research, no do not use wide public as test subjects) | 18:27 |
| LjL | you also have confounders the other way, that is with almost everyone being vaccinated, when you try to study vaccinated vs "unvaccinated", you find few differences because the unvaccinated are really just the not-recently-boosted | 18:27 |
| peetaur | yes the 2 confounders I listed are one side, but there are always more ways | 18:28 |
| LjL | confounders all over the place, and yet you "know" despite it being with low certainty that the vaccine is actually detrimental | 18:28 |
| peetaur | yes I know because you can always assume an untested experimental medication will do more harm than good, just like any other tested med will in the wrong use case | 18:29 |
| peetaur | I know. With some uncertainty. But I know. | 18:29 |
| Brainstorm | (Matrix) <pwr22> What is the better solution? | 18:30 |
| peetaur | you mean how to reduce T2D? just stop eating junk food | 18:30 |
| LjL | you could say the same of *every* medication since they're almost always tested by clinical trials sponsored by whoever's making the medication... same as you accused the vaccines of, and sure, this is actually a problem with medicine, yet overall we live longer and better thanks to it | 18:30 |
| Brainstorm | (Matrix) <pwr22> What is T2D? | 18:30 |
| peetaur | "stop eating junk food" doesn't come in pill form though | 18:31 |
| peetaur | type 2 diabetes mellitus | 18:31 |
| LjL | it's hard to argue *against* good diets, but it's very easy to argue against good diet as a *replacement for medicine* | 18:32 |
| Brainstorm | (Matrix) <pwr22> "Stop eating junk food" <- if it were this simple, no one would be overweight and everyone would be peak fitness. It is no doubt an excellent thing to do but you have to do things that will actually work with real human beings. It's easy to assert anything ideologically that way 😛 | 18:32 |
| peetaur | it is not that simple for many addicts to quit, true | 18:32 |
| Brainstorm | (Matrix) <pwr22> The closest thing we have to medicating that is likely the GLP analogues that are in vogue | 18:32 |
| LjL | you're being the typical "i am right because i just assume i am right" anti-vaxxer just with more knowledge about medical research sprinkled around that, but then you proceed to ignore it and go on your feelings about medicine | 18:33 |
| peetaur | you mean like ozempic? that stuff sounds like a disaster with people claiming permanent damage | 18:33 |
| peetaur | generalizing doesn't fix anything...only leads to lost opportunity | 18:34 |
| Brainstorm | (Matrix) <pwr22> So many people are overweight when given ready access to modern food and luxuries (like not having to walk everywhere / driving etc), that I'd say it's actually a minority who are constitutionally dialled in to weather that scenario healthily | 18:34 |
| peetaur | everyone with more knowlege has a license they can lose if they speak out | 18:34 |
| Brainstorm | New from Il Sole 24 Ore: (translated) Health: *Covid, vaccine free for #all but recommended to *over 60 fragile and women in pregnancy → https://www.ilsole24ore.com/art/covid-vaccino-gratis-tutti-ma-raccomandato-over-60-fragili-e-donne-gravidanza-AFpyBJyD | 18:35 |
| Brainstorm | (Matrix) <pwr22> Yeah ozempic and friends. There's also lots of people taking it and lots of studies showing increased longevity beyond what you'd expect from calorie reduction etc. Cardio protective effects etc. | 18:35 |
| peetaur | calorie reductuion is a failure... comparing one failure to another isn't a good strategy | 18:35 |
| Brainstorm | (Matrix) <pwr22> goalposts, they shift, like a leaf, in the breeze | 18:35 |
| LjL | %tr La campagna nazionale di vaccinazione autunnale e invernale anti Covid-19 2024-25 utilizzerà vaccini adattati alla variante JN.1 | 18:36 |
| Brainstorm | LjL, Italian to English: The 2024-25 national Covid-19 autumn and winter vaccination campaign will use vaccines adapted to the JN.1 variant (Google: 18%) — The national autumn and winter vaccination campaign against Covid-19 2024-25 will use vaccines adapted to the JN.1 variant (MyMemory: 16%) [... want %more?] | 18:36 |
| LjL | fuck this shit, i was already annoyed that we don't adapt it to the *latest* variant, but in this case we have KP.2 vaccines but no, we're just going to use the older ones | 18:36 |
| Brainstorm | (Matrix) <pwr22> Gotta use up that old stock 😉 | 18:36 |
| Brainstorm | (Matrix) <pwr22> Are they also going to give it to the first people (so the most vulnerable) ? | 18:37 |
| Brainstorm | (Matrix) <pwr22> That's a UK big brain strategy | 18:37 |
| peetaur | the problem with moving goal posts is when people lose and they want to be able to win just because they want to win; but this is about knowlege...and setting new goals for what you accept as quality evidence is just fine | 18:37 |
| peetaur | in science, if you fail but learn, you won | 18:37 |
| LjL | pwr22: i'm not sure, it says it will be free for everyone but recommended to specifically categories, it doesn't say whether they will actually get priority | 18:38 |
| LjL | but i guess i shouldn't complain too much given the UK just doesn't provide it except for specific categories | 18:38 |
| peetaur | are you in an at-risk group? do you have metabolic syndrome, t2d, atherosclerosis (also all related to junk food)? | 18:39 |
| LjL | no | 18:39 |
| Brainstorm | (Matrix) <pwr22> It irks me that they keep saying it is available for those "vulnerable" but they've changed what that means | 18:39 |
| peetaur | and re "argue *against* good diets" ... they've been successfully doing it for years. Tell me, what's healthier, bacon, or brown rice? | 18:40 |
| peetaur | everyone thinks there's something wrong with bacon, but in reality, it's a health food compared to brown rice | 18:40 |
| Brainstorm | (Matrix) <pwr22> There's people out there that can get heart disease even when they are healthy in both diet and exercise, there are other factors too | 18:40 |
| peetaur | have you heard of tuft's food compass, putting lucky charms above stuff like bacon in how healthy it is? :D that kind of crap continues for ages | 18:40 |
| peetaur | pwr22 how many of them only think they have a healthy diet, but they're eating soy and corn and rice and that stuff instead of bacon? | 18:41 |
| LjL | yes, nobody argues against having a good diet, but there's definitely confusion around what counts as a good diet. but still, it's a false dichotomy to say "well you don't have to use any medicines since they're tested with a conflict of interest, when you can just have a good diet instead" | 18:41 |
| Brainstorm | (Matrix) <pwr22> Wait, do you want them eating Bacon? | 18:41 |
| peetaur | bacon is delicious... your evolved tastes are trying to tell you something | 18:41 |
| peetaur | bacon is near the top best thing, but not the best thing ... so yes | 18:42 |
| peetaur | but everyone loves bacon, so let's start there | 18:42 |
| Brainstorm | (Matrix) <pwr22> What do you think about the link between that and bowel cancer? | 18:42 |
| LjL | pwr22, don't you know, it's delicious, that beats any scientific-method trial of it | 18:42 |
| peetaur | pwr22: complete nonsense, based on flawed observational studies | 18:42 |
| peetaur | in general, with highly natural things (think what your great grandma ate, not what you get made in a laboratory today), taste works very well, and beats this thing they call science but is really politics and marketing | 18:43 |
| peetaur | (and actual science is the best way we know to learn about everything observable) | 18:44 |
| LjL | (* when it agrees with our prior biases) | 18:45 |
| peetaur | (science like... paleoanthropology, which says the more meat they ate, the larger their brains, the taller they were, the stronger they were, the fewer dental caries they have, etc.) | 18:45 |
| peetaur | nope... true knowlege comes from admitting when you're wrong | 18:45 |
| peetaur | show me a true interventional study done on humans that says tofu is healthier than bacon | 18:45 |
| peetaur | I eat a 90% meat diet 99% animal based diet... my triglyceride level is 1.03 mmol/L, HDL is 1.35, and LDL is 2.368 (irrelevant). How about you? | 18:50 |
| peetaur | I don't "exercise" because my daily lifestyle is already active enough to tire me out.... hobby farming | 18:52 |
| Brainstorm | (Matrix) <pwr22> People in my great grandma's day lived a damn shorter time 😛 | 19:05 |
| Brainstorm | (Matrix) <pwr22> It's good that you're able to keep active enough just doing what you need / want to do 🙂 | 19:08 |
| peetaur | the stats are not so clear about how long they lived back then... nowadays the infant mortality rate is down, and other diseases kill less (due to antibiotics etc.) so how long would they have lived if they also had these improvements? we don't know | 19:16 |
| peetaur | I have a great grandfather than lived to 110 or something and was the worst chain smoker possible ...so therefore smoking is good, right? ;) | 19:17 |
| peetaur | confounders...always | 19:17 |
| Brainstorm | New from Contagion Live: Metformin Linked to Lower Risk of Long COVID and Death in Diabetes Patients: Adults with type 2 diabetes who use metformin have a 13% to 21% reduced risk of developing Long COVID or dying from COVID-19 compared to those taking other [... want %more?] → https://www.contagionlive.com/view/metformin-linked-to-lower-risk-of-long-covid-and-death-in-diabetes-patients | 20:03 |
| Brainstorm | New from Il Sole 24 Ore: (translated) Of the *ricoveri to the absences to work: the escape of the vaccines *Covid coast 1,6 *miliardi: #If of the fine of the emergency are counted almost *8mila died #the one who #be not always notice #be the cheap impact of the lacked vaccination → https://www.ilsole24ore.com/art/dai-ricoveri-assenze-lavoro-fuga-vaccini-covid-costa-16-miliardi-AFMVzPwD | 20:32 |
| Brainstorm | New from CIDRAP: Evidence growing for COVID antivirals to cut poor outcomes, long COVID, experts say: A study suggesting that nirmatrelvir/ritonavir and molnupiravir don't prevent severe COVID-19 outcomes or long COVID is also being called into question. → https://www.cidrap.umn.edu/covid-19/evidence-growing-covid-antivirals-cut-poor-outcomes-long-covid-experts-say | 22:29 |
| Brainstorm | New from Reddit (test): CoronavirusUK: More than 165,000 Scots suffering from long Covid, new report reveals → https://old.reddit.com/r/CoronavirusUK/comments/1fja45u/more_than_165000_scots_suffering_from_long_covid/ | 22:39 |
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