| Brainstorm | New from MedPageToday: Alzheimer's Biomarkers Show Tantalizing Hint at Utility for Tracking Prevention: (MedPage Today) -- PHILADELPHIA -- Blood tests for Alzheimer's disease biomarkers may not only be useful for clinical diagnosis but could also make it possible to test preventive therapies in people not yet [... want %more?] → https://www.medpagetoday.com/meetingcoverage/aaic/111288 | 00:08 |
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| Brainstorm | New from Marc Veldhoen on Mastodon: (news): By field trips, cloning and testing in laboratories, cell lines and animal models. When you do, you confirm that diverse bat coronaviruses evade interferon and downregulate major histocompatibility complex class I, jiudt like SARS-COV-2. → https://mastodon.online/@marc_veld/112872212007012233 | 00:59 |
| ublix | Submission received: 21 May 2024 / Revised: 17 July 2024 / Accepted: 22 July 2024 / Published: 28 July 2024 - https://www.mdpi.com/1422-0067/25/15/8245 | 01:30 |
| ublix | "SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia" | 01:30 |
| Brainstorm | New from r/Coronavirus: Coronavirus: Virus that causes COVID-19 is widespread in wildlife, scientists find → https://old.reddit.com/r/Coronavirus/comments/1eff0q0/virus_that_causes_covid19_is_widespread_in/ | 02:09 |
| Brainstorm | New from r/COVID19: COVID19: Incidence of hearing loss following COVID-19 among young adults in South Korea: a nationwide cohort study → https://old.reddit.com/r/COVID19/comments/1effkw1/incidence_of_hearing_loss_following_covid19_among/ | 02:29 |
| Brainstorm | New from BMJ Open: Characteristics of mental skills interventions in dance: a mixed methods systematic review protocol: Introduction Dancers are expected to navigate major challenges in their careers that might take a toll on their physical and mental health. To address underlying factors that might increase dancers’ [... want %more?] → http://bmjopen.bmj.com/cgi/content/short/14/7/e086345 | 04:30 |
| Brainstorm | New from r/COVID19: COVID19: Have any long haulers had success results with Stanford Post Covid Clinic? → https://old.reddit.com/r/COVID19/comments/1efk45z/have_any_long_haulers_had_success_results_with/ | 06:13 |
| Brainstorm | New from r/COVID19: COVID19: Widespread exposure to SARS-CoV-2 in wildlife communities → https://old.reddit.com/r/COVID19/comments/1efl0a9/widespread_exposure_to_sarscov2_in_wildlife/ | 07:02 |
| Brainstorm | New from PubMed: How to treat major depressive disorder with shorter-duration hypomanic episodes? A case report: Here we report on a case of a 61-year-old female patient with 7-year history of major depressive disorder with shorter-duration hypomanic episodes who was prescribed with antidepressants which turned out to be [... want %more?] → https://pubmed.ncbi.nlm.nih.gov/39077629/ | 12:46 |
| Brainstorm | New from BioNTech: BioNTech Announces Positive Topline Phase 2 Results for mRNA Immunotherapy Candidate BNT111 in Patients with Advanced Melanoma: Primary endpoint met in a Phase 2 trial evaluating the investigational mRNA immunotherapy BNT111 in [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/biontech-announces-positive-topline-phase-2-results-mrna | 12:57 |
| Brainstorm | New from Reddit (test): COVID19_Pandemic: Ziyad Al-Aly on Twitter: "COVID increases risk of diabetes. This has now been demonstrated in many studies including the largest (more than 16 million) in @TheLancetEndo…" → https://old.reddit.com/r/COVID19_Pandemic/comments/1efqdjk/ziyad_alaly_on_twitter_covid_increases_risk_of/ | 14:08 |
| Brainstorm | New from EMA: What's new: (news): Human medicines European public assessment report (EPAR): VidPrevtyn Beta, COVID-19 Vaccine (recombinant, adjuvanted), Date of authorisation: 10/11/2022, Revision: 4, Status: Withdrawn (authorisation) → https://www.ema.europa.eu/en/medicines/human/EPAR/vidprevtyn-beta | 14:39 |
| peetaur | heh... usually they say the opposite of this confounded inconclusive conclusion based on mere correlation... diabetes increases risk of severe COVID; why did they reverse it today? | 14:57 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: We’re reading about the U.K. nixing coverage for a cancer drug, sharing bird flu vaccine data, and more → https://www.statnews.com/pharmalot/2024/07/30/medicare-nhs-cancer-astrazeneca-enhertu-sanofi-sarepta-duchenne-bird-flu-vaccine/ | 15:41 |
| LjL | peetaur, hardly "today", there's been several papers claiming COVID increases risk of diabetes... | 17:30 |
| peetaur | and are any actually good quality science? that one says "more than 16 million" meaning it's observational, so not a good place to draw strong conclusions | 17:30 |
| LjL | i don't know, i'm just saying it's not a new claim | 17:31 |
| LjL | https://www.zotero.org/groups/4391070/covid_links/search/diabetes/titleCreatorYear | 17:31 |
| Brainstorm | New from LitCovid: (news): Chronic inflammatory demyelinating polyneuropathy following COVID-19 vaccination: a case report and literature review. → https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/39075432 | 17:33 |
| peetaur | thanks for the link ... skimmed 5 of those so far, and nothing stands out as eliminating confounders, like testing whether they have diabetes just before covid and after, and seeing it changed | 17:35 |
| peetaur | is it common knowlege yet that T2D can be reversed (put in remission forever)? | 17:38 |
| peetaur | https://www.cidrap.umn.edu/new-type-2-diabetes-diagnoses-youth-climbed-77-amid-covid-19 says 77% ...ummm that's a lot | 17:38 |
| peetaur | "Now is the time to focus on exercising and a healthy diet for your kids," co-first author Sheela Magge, MD, said in the Johns Hopkins release. | 17:43 |
| peetaur | I love how they say that, and leave "healthy diet" undefined, so the poor souls who then go to the government diet plan and follow that advice will be going even further from "healthy diet" | 17:43 |
| peetaur | to do that in context they should point at a study that shows what diet can actually prevent or undo this damage; goverment guidelines have no scientific support...and lots of criticism, so not that. | 17:44 |
| ublx | haven't got around to reading it yet, but "Ultra-Processed People - The Science Behind Food That Isn't Food" by Van Tulleken, from the Absence of Negative school of thought, seems like it may be an interesting guide | 17:50 |
| ublx | not that the ultimate message sounds terribly complex (just don't eat processed foods) | 17:51 |
| peetaur | yep that's a huge part of the solution (but also "processed food" is badly defined... eg. ground beef is just as good or better than what you ground, other than potential contaminants; but ground up flour is now higher glycemic load than before; and some would say 'isolates' which are even more processed can be better than the original because they removed some lectins and such) | 17:53 |
| peetaur | for example NOVA classifies sausages as highly processed ... which is dumb; buy a proper one and it's just ground meat with spices... no part of that "processing" has made it worse | 17:54 |
| ublx | can you get 'proper' sausages in the average supermarket though? | 17:54 |
| ublx | wonder what the population carrying capacity of the food supply chain would be, after elimination of all industrially produced ultra processed foods | 17:58 |
| ublx | not 8 billion anyway | 17:58 |
| peetaur | we know of a few butcher shops that have proper enough sausages. There are a few brands at supermarkets that are also good enough... like the PC brand "free from" has a clean enough ingredient list, but who knows what kind of factory farms they run. | 17:59 |
| peetaur | pretty sure if you remove ultraprocessed food, the capacity goes up... because the addiction to worthless nutritionless "food" goes down | 17:59 |
| ublx | maybe, but the transition would be challenging | 18:00 |
| peetaur | I think a slow transition isn't so bad, but takes time before you figure out how to even find a single thing in the stores without questionable ingrdients or processing ;) | 18:06 |
| peetaur | many people just say go in the outside aisles... fruit and veggies and whole cuts of meat, etc. and prepare all your own food. That works...but it's more sudden than some want probably. | 18:06 |
| peetaur | and apeel coating on stuff complicates that... now that's a thing on the outer aisles you most likely surely shouldn't eat | 18:07 |
| peetaur | (and I'm used to it by now after decades... less variety if you're on the road especially, but always works... and I remain in near perfect health... never noticed if I ever had sars-cov-2) | 18:09 |
| ublx | well we'd need to clone ten thousand peetaurs and re-run the experiment to draw definitive conclusions :p | 18:12 |
| peetaur | well it's not just me doing something like this ... but yeah something like that would make the results more conclusive ;) | 18:13 |
| ublx | on a slightly darker note, i hope you're not too blase about the "never noticed if I ever had sars-cov-2" part - if you're very healthy, this part could be interpreted as you having very large functional reserve in your various organs, rather than that you haven't been harmed however slightly by an unsymptomatic infection | 18:15 |
| ublx | i mean, any infection that nibbles away at functional reserves is a harm, is aging, if you will | 18:15 |
| peetaur | not sure what you mean there... what's darker about having enough reserve to not notice any impairment in function? | 18:27 |
| peetaur | (other than asymptomatic meaning maybe spread it unknowingly ...which can be said without anything else you said above I think) | 18:27 |
| ublx | in the sense of aging being the accumulation of impairments | 18:28 |
| peetaur | so you're just basically saying maybe after x times, symptoms appear, or whatever future symptoms from age appear earlier | 18:30 |
| ublx | pretty much | 18:31 |
| ublx | if you were an olympic athlete, symptoms might have already appeared, since it is the business of athletes to explore and push limits (of their lungs for example) | 18:32 |
| ublx | say, a professional athlete might readily notice a 5% drop in VO2 max (via routine testing) whereas an inactive office worker could go a decade without noticing this | 18:34 |
| ublx | i'm js, if you're going nth degree in food related health, might as well not be blase about infections and the impact they might have on carrying health as far as possible into old age | 18:36 |
| ublx | life is a balance act in the end | 18:36 |
| ublx | *balancing | 18:36 |
| ublx | no matter how exquisitely healthy your choices are, there will come an age (60, 70, 90?) where your age-related functional reserves will have you notice the immediate effects of certain infections | 18:41 |
| ublx | functional reserve helps postpone that day, as does avoiding things that nibble away at the reserve | 18:41 |
| ublx | such as bugs. they're not pokemon. you don't have to catch them all | 18:42 |
| peetaur | but if I do catch them all and continue to have some functional reserve, it'll stay at that level forever right? | 18:43 |
| peetaur | won the game? | 18:43 |
| ublx | the bug factory gets a vote. it never rests | 18:44 |
| Brainstorm | (Matrix) <LjL> Not sure if common, I've encountered that piece of knowledge before, but I probably search for more medical stuff than the average person... | 19:21 |
| Brainstorm | New from ScienceNews: Earth’s jet stream helps create the seeds of clouds: The newly discovered process for making aerosols might also be the most productive. → https://www.sciencenews.org/article/earth-jet-stream-help-create-seed-cloud | 19:25 |
| Brainstorm | (Matrix) <LjL> Someone my parents know (their age) had a pretty horrible skiing accident in his youth, spent a lot of time not moving with a leg permanently injured, but had otherwise been a very active person and the doctor told him he could probably continue hiking and skiing as long as he'd keep exercising the leg. But they also warned him that eventually as he'd get old, a time would come when no mat[cutoff] | 19:26 |
| Brainstorm | (Matrix) <LjL> ter the exercise, the leg just wouldn't hold anymore (not sure why the cruelty of telling him this!). | 19:26 |
| Brainstorm | (Matrix) <LjL> He told us this stuff because that time came last year, he sold his Alps house as he was obviously limping, couldn't hike anymore by any means | 19:26 |
| ublx | well it's the patients choice, where to strike the balance, between guarding and rehabilitating an injury for longer hobble free life, vs risking exacerbating it with various activities now for a perceived fuller life | 19:33 |
| ublx | surely also the patient has to have the opportunity where possible to be mentally prepared for future adversity - hard to divine from a stranger whether their psyche is of the ignorance is bliss sort. at any rate, far from obvious that landscape of decision is the nearer the doctor's prerogative than the patient's | 19:35 |
| Brainstorm | New from StatNews: CDC will offer seasonal flu shots to farmworkers to lower bird flu risk: The CDC funding a $5 million program to vaccinate livestock industry workers against seasonal flu in a bid to reduce the pandemic risk posed by the ongoing H5N1 bird flu… → https://www.statnews.com/2024/07/30/cdc-offers-farmworker-seasonal-flu-shots-latest-news-bird-flu-outbreak/ | 19:55 |
| Brainstorm | New from StatNews: STAT+: Merck shares fall as sales of HPV vaccine drop in China: Shares of Merck fell 9% after the company reported that in the second quarter, it saw a decrease in shipments of its HPV vaccine Gardasil in China. → https://www.statnews.com/2024/07/30/merck-hpv-vaccine-china/ | 20:05 |
| Brainstorm | New from CIDRAP: CDC study highlights COVID's impact on infection control, multidrug-resistant pathogens in hospitals: Changes in infection control practices and strategies to conserve personal protective equipment may have played a role in MDRO [... want %more?] → https://www.cidrap.umn.edu/antimicrobial-stewardship/cdc-study-highlights-covids-impact-infection-control-multidrug-resistant | 20:36 |
| Brainstorm | New from CIDRAP: (news): Young adults at higher risk of hearing loss after COVID infection, data suggest → https://www.cidrap.umn.edu/covid-19/young-adults-higher-risk-hearing-loss-after-covid-infection-data-suggest | 22:07 |
| Brainstorm | New from MedPageToday: In Bird Flu Fight, CDC Plans Seasonal Flu Shot Push for Farmworkers: (MedPage Today) -- The CDC is investing $10 million in a major push to get livestock workers vaccinated for seasonal influenza before the upcoming respiratory season, the agency announced on Tuesday.Of the $10 million [... want %more?] → https://www.medpagetoday.com/infectiousdisease/uritheflu/111303 | 23:18 |
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