| ublix | it does suck for lip readers though, idk what's wrong with acknowledging that | 00:02 |
|---|---|---|
| LjL | ublx, nothing, just the D/d since as usual i look at form over substance | 00:09 |
| ublx | ah hrm. my eyes glossed straight over that | 00:09 |
| ublx | idk what that is about | 00:09 |
| ublx | some deaf prefer get upset if they're not capitalised and some other deaf people get upset if they're not capitalised? | 00:10 |
| ublx | *minus one not | 00:11 |
| LjL | probably, yes | 00:11 |
| LjL | "Deaf" with a capital D refers to a culture or self-identification or something like that | 00:11 |
| LjL | anyway, aside from that | 00:11 |
| LjL | The masks section of a 2023 Cochrane review of non-pharmaceutical interventions (9) was—controversially—limited to randomized controlled trials (RCTs). It was interpreted by the press and by some but not all of its own authors to mean that “masks don’t work” and “mask mandates did nothing” (10). Cochrane’s editor-in-chief felt the need to state publicly that in Cochrane’s view, the review’s findings did not support such a conclusion (11). Some s | 00:12 |
| LjL | cholars were quick to question the review’s methodology, especially key flaws in the meta-analysis and omission of a vast body of non-RCT evidence (12–16). | 00:12 |
| LjL | ... i thought RCTs were good? ;( | 00:12 |
| LjL | that review ( https://pubmed.ncbi.nlm.nih.gov/36715243/ ) finds the studies were however "meh" and so the quality of evidence is moderate/low and it doesn't show an advantage | 00:12 |
| LjL | so we have a review picking fights with another review? | 00:12 |
| ublx | i think at the time the goalposts for controversy might have been.. deranged | 00:13 |
| Brainstorm | New from r/COVID19: COVID19: SARS-CoV-2 breakthrough infections enhance T cell response magnitude, breadth, and epitope repertoire → https://old.reddit.com/r/COVID19/comments/1cyct8d/sarscov2_breakthrough_infections_enhance_t_cell/ | 00:15 |
| LjL | what time? it's a recent paper | 00:15 |
| ublx | the 2023 cochrane review brouhaha? | 00:15 |
| LjL | well, 2023 is also "over the pandemic" isn't it | 00:16 |
| ublx | that's.. controversial | 00:16 |
| LjL | The Cochrane review of non-pharmaceutical interventions, for example, appears to rest on the assumption that trustworthy evidence on this topic comes primarily or exclusively from RCTs and that if RCTs have been identified, non-RCT evidence can be ignored (9). An alternative view is that evidence-based medicine’s “hierarchy of evidence” (with RCTs as the assumed gold standard) is inappropriate for multifaceted topics such as masking (12, 14, 18, 19). | 00:16 |
| LjL | Some have argued that the scientific value of the RCT has become inflated, particularly among doctors, leading them to overlook high-quality non-RCT evidence | 00:16 |
| LjL | i think it's probably so hard to make good trials about masks and the subject is so politically charged that you could make studies *and* reviews going one way or the other, or at least, someone like me will have no hope of assessing the validity of evidence presented :( | 00:18 |
| ublx | politically charged.. i saw some stories recently about two or three states in the US actually introducing mask bans! | 00:20 |
| ublx | hmm, only reference i can find right now is for North Carolina: | 00:22 |
| ublx | %title https://www.thegauntlet.news/p/biden-cdc-silent-as-north-carolina | 00:22 |
| Brainstorm | ublx: From www.thegauntlet.news: Biden, CDC silent as North Carolina lawmakers vote to ban masks | 00:22 |
| LjL | yes, i saw that | 00:30 |
| LjL | it's technically abolishing an exception, as they had a ban on masks before, dating from the 50s due to the KKK | 00:31 |
| ublx | heh | 00:33 |
| ublx | from among a flurry of articles over the last few hours on bird/cow flu: https://www.statnews.com/2024/05/22/bird-flu-in-humans-michigan-reports-h5n1-infection-in-dairy-farm-worker/ | 00:42 |
| Brainstorm | New from ##covid-19 Zotero group: Masks and respirators for prevention of respiratory infections: a state of the science review: Item Type Journal Article Author Trisha Greenhalgh Author C. Raina MacIntyre Author Michael G. Baker Author Shovon Bhattacharjee Author Abrar A. Chughtai Author David Fisman Author Mohana [... want %more?] → https://www.zotero.org/groups/covid_links/items/FQ9MAZNV | 00:44 |
| Brainstorm | New from r/WorldNews: worldnews: US ‘concerned’ by Israel’s isolation, Biden national security adviser says → https://old.reddit.com/r/worldnews/comments/1cye0gb/us_concerned_by_israels_isolation_biden_national/ | 01:23 |
| Brainstorm | New from Politico: 5 awkward WhatsApps as UK’s top civil servant faces Covid inquiry: Simon Case gives evidence after scathing comments about how Whitehall functioned during the crisis. → https://www.politico.eu/article/cabinet-secretary-simon-case-whatsapp-covid-inquiry-boris-johnson-partygate-downing-street/ | 04:16 |
| Brainstorm | (Matrix) <LeftFootofAllah> COVID-19 WAS THE WORLD GOVERNMENT COVERUP OF THE REIGN OF THE ANTICHRIST | 04:31 |
| Brainstorm | New from StatNews: Fresh scrutiny of post-Covid spending reignites yearslong tension over emergency stockpiles: The Biden administration is engaged in an internal fight over funding that reflects a long-simmering debate about national strongholds of emergency medical equipment. → https://www.statnews.com/2024/05/23/aspr-pandemic-preparedness-funding-omb/ | 10:34 |
| Brainstorm | New from BBC Health: (news): Watch: Civil servant Simon Case in delayed Covid inquiry appearance → https://www.bbc.co.uk/news/live/uk-69052575 | 11:24 |
| Brainstorm | New from BMJ: Summary of WHO infection prevention and control guideline for covid-19: striving for evidence based practice in infection prevention and control: The World Health Organization (WHO) published the seventh version of the infection prevention and control guideline for coronavirus disease 2019 (covid-19) in December [... want %more?] → http://www.bmj.com/content/385/bmj.q645.short | 12:07 |
| Brainstorm | New from PubMed: Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities: INTRODUCTION: Antibodies against the SARS-CoV-2 spike protein are a critical immune determinant for protection against the virus. While virus neutralization is a key function of [... want %more?] → https://pubmed.ncbi.nlm.nih.gov/38779671/ | 12:46 |
| Brainstorm | New from BMJ: A rare cardiac mass: A new systolic heart murmur was identified in a woman in her mid-60s during a preoperative assessment (fig 1). She had completed a course of radiotherapy and chemotherapy for rectal cancer (stage T4b N1b M0), followed by uncomplicated elective robotic low anterior resection and [... want %more?] → http://www.bmj.com/content/385/bmj-2023-078072.short | 13:36 |
| Brainstorm | New from EMA: What's new: (news): Veterinary medicines European public assessment report (EPAR): Strangvac, Streptococcus equi vaccine (recombinant proteins), Status: Authorised → https://www.ema.europa.eu/en/medicines/veterinary/EPAR/strangvac | 13:56 |
| Brainstorm | New from StatNews: Adam's Take: STAT+: Cytokinetics CEO Robert Blum is on my Worst CEO shortlist again, and other thoughts → https://www.statnews.com/2024/05/23/cytokinetics-ceo-robert-blum/ | 14:15 |
| Brainstorm | New from ScienceNews: Two real-world tests of quantum memories bring a quantum internet closer to reality: Scientists successfully entangled quantum memories linked by telecommunications fibers across two different urban environments. → https://www.sciencenews.org/article/quantum-physics-memories-internet | 15:34 |
| Brainstorm | New from StatNews: In light of H5N1 outbreak, U.S. in talks with mRNA vaccine makers on bird flu: Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Good morning. Wall Street [... want %more?] → https://www.statnews.com/2024/05/23/biotech-news-h5n1-bird-flu-vaccine-mrna-cytokinetics-gilead-bicycle-therapeutics-obesity/ | 15:44 |
| Brainstorm | New from r/WorldNews: worldnews: South African firm partners with Nobel-winning scientist to develop mRNA vaccines that target diseases that have plagued Africa for decades → https://old.reddit.com/r/worldnews/comments/1cyt22u/south_african_firm_partners_with_nobelwinning/ | 16:04 |
| Brainstorm | New from r/Science: science: L9LS, a monoclonal antibody with an extended half-life, targets highly conserved junctional PfCSP epitope. It protects both children and adults against Plasmodium falciparum infection and clinical malaria. → https://old.reddit.com/r/science/comments/1cyt8j7/l9ls_a_monoclonal_antibody_with_an_extended/ | 16:24 |
| Brainstorm | New from MedPageToday: Middle School HPV Vaccination Program Boosted Uptake: (MedPage Today) -- An at-school vaccination program in France significantly increased human papillomavirus (HPV) vaccine coverage, according to results of the PrevHPV cluster randomized trial.Among girls and boys ages 11 to 14 years, [... want %more?] → https://www.medpagetoday.com/infectiousdisease/vaccines/110287 | 17:24 |
| Brainstorm | New from ProPublica: Texas Appeals Court Orders Dismissal of Lawsuit Against ProPublica, Texas Tribune: by Perla Trevizo ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. This article is [... want %more?] → https://www.propublica.org/article/mrg-medical-lawsuit-dismissed-against-propublica-texas-tribune | 17:34 |
| Brainstorm | New from Politico: 5 revelations you missed at the Simon Case Covid grilling: Civil service boss apologizes at the UK's pandemic inquiry — which risked being overshadowed by the election. → https://www.politico.eu/article/uk-simon-case-cabinet-secretary-covid-grilling-revelations-sunak-johnson/ | 19:12 |
| Brainstorm | New from Reddit (test): CoronavirusUK: Long Covid teachers join forces to sue ministers → https://old.reddit.com/r/CoronavirusUK/comments/1cyyjdq/long_covid_teachers_join_forces_to_sue_ministers/ | 19:41 |
| Brainstorm | New from Il Sole 24 Ore: (translated) Of *Astrazeneca to *Roche, the pharmaceutical in the era of the new #anti *tumorali: Here how they capsize the multiples of the sector in #Burse: the analysts look to the future of the products for the *oncologia in a market of 440 *miliardi → https://www.ilsole24ore.com/art/da-astrazeneca-roche-farmaceutici-nell-era-nuovi-anti-tumorali-AGiTXRB | 20:10 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): Neutralising antibodies determine susceptibility to infection (not disease). These wane months after infection, but you will on average have enough to ward off infection for >6-8 months. → https://mastodon.online/@marc_veld/112491864076857517 | 20:49 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): after the mass-vaccination efforts, reducing viral circulation, synchronising population level immunity, reducing hospitalisations and mortality as well as pushing the virus more and more into a annual pattern. → https://mastodon.online/@marc_veld/112492459004868112 | 23:17 |
| Brainstorm | New from StatNews: The HPV vaccine prevents cancer in men, too. Why do so few people get it?: There is not really any debate, at this point, that the HPV vaccine would prevent tens of thousands of cases of cancer a year if it were used more widely. → https://www.statnews.com/2024/05/23/hpv-vaccine-cancer/ | 23:27 |
| Brainstorm | New from Contagion Live: Mpox Vaccine is 99.2% Efficacious Against Infection: The vaccine, Jynneos (Bavarian Nordic), is an FDA-approved vaccine for mpox, and is now available for commercial purchase in the United States. → https://www.contagionlive.com/view/mpox-vaccine-is-99-2-efficacious-against-infection | 23:55 |
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